Southbound lanes of Highway 101 were closed on Tuesday evening after a fatal crash.
According to the California Highway Patrol, the crash occurred at Grand Avenue in South San Francisco at around 7:05 p.m.
CHP officers said it was a vehicle versus a pedestrian case where a man was hit and killed while on foot.
Officers reported that the victim was possibly struck by a Ford van but they believe more than one vehicle hit the victim.
No other injuries were reported.
All southbound lanes were closed immediately after the crash. The left two lanes have since reopened. There is no estimated time for the other lanes to reopen.